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In this PhD thesis, Yue Yanan addresses a long-overlooked and critical question in the development of non-viral vectors for gene delivery. The author determines that those uncomplexed and cationic polymer chains free in the solution mixture of polymer and DNA facilitate and promote gene transfection. Furthermore, by using a combination of synthetic chemistry, polymer physics and molecular biology, Yue confirms that it is those cationic polymer chains free in the solution mixture, rather than those bound to DNA chains, that play a decisive role in intracellular trafficking. Instead of the previously proposed and widely accepted “proton sponge” model, the author's group propose a new hypothesis based on the results of several well-designed and decisive experiments. These results show that free polycationic chains with a length of more than ~10 nm are able to partially block the fusion between different endocytic vesicles, including the endocytic-vesicle-to-endolysosome pathway. This thesis is highly original and its results greatly deepen our understanding of polymer-mediated gene transfection. More importantly, it provides new insights into the rational design of next-generation superior polymeric gene-delivery vectors.

Chemistry --- Physical Sciences & Mathematics --- Organic Chemistry --- Addition polymerization. --- Anionic polymerization --- Cationic polymerization --- Chain addition polymerization --- Free-radical polymerization --- Ionic polymerization --- Chemistry. --- Organic chemistry. --- Polymers. --- Nucleic acids. --- Polymer Sciences. --- Organic Chemistry. --- Nucleic Acid Chemistry. --- Polymerization --- Chemistry, Organic. --- Polynucleotides --- Biomolecules --- Organic chemistry --- Polymere --- Polymeride --- Polymers and polymerization --- Macromolecules --- Polymers  .

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Polymers --- Polymers. --- Polymere --- Polymeride --- Polymers and polymerization --- Macromolecules --- Organic Chemistry

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During the last ten to fifteen years the developments in polymer science has been striking attention and undergone important changes. From rather specialized subject intended for engineers interested in certain definite fields, it has developed into one of the fundamental disciplines common to several branches of engineering and science. To serve this purpose, the subject materials have been prepared to treat a comprehensive aspects of polymer science. Following this trend, a number of rigorous books have discussed different types of polymers with great precision and elegance and at relatively high levels of abstraction, but none is complementary. A position midway between the older, traditional approach in engineering and the recent, somewhat formal expositions seems to be evolving.

Polymerization. --- Polymers. --- Polymere --- Polymeride --- Polymers and polymerization --- Macromolecules --- Polymerisation --- Polymers --- Synthesis of polymers --- Chemical reactions --- Synthesis --- Polymer chemistry

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How can a scientist or engineer synthesize and utilize polymers to solve our daily problems? This introductory text, aimed at the advanced undergraduate or graduate student, provides future scientists and engineers with the fundamental knowledge of polymer design and synthesis to achieve specific properties required in everyday applications. In the first five chapters, this book discusses the properties and characterization of polymers, since designing a polymer initially requires us to understand the effects of chemical structure on physical and chemical characteristics. Six further chapters discuss the principles of polymerization reactions including step, radical chain, ionic chain, chain copolymerization, coordination and ring opening. Finally, material is also included on how commonly known polymers are synthesized in a laboratory and a factory. This book is suitable for a one semester course in polymer chemistry and does not demand prior knowledge of polymer science.

Polymer engineering. --- Polymers --- Polymerization --- Chemistry --- Physical Sciences & Mathematics --- Organic Chemistry --- Polymers. --- Polymerization. --- Polymerisation --- Polymers and polymerization --- Synthesis of polymers --- Polymere --- Polymeride --- Synthesis --- Chemistry. --- Industrial engineering. --- Production engineering. --- Materials science. --- Polymer Sciences. --- Industrial and Production Engineering. --- Characterization and Evaluation of Materials. --- Macromolecules --- Chemical reactions --- Surfaces (Physics). --- Management engineering --- Simplification in industry --- Engineering --- Value analysis (Cost control) --- Physics --- Surface chemistry --- Surfaces (Technology) --- Polymers  . --- Material science --- Physical sciences --- Manufacturing engineering --- Process engineering --- Industrial engineering --- Mechanical engineering

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Molecular imprinting --- Imprinted polymers --- Imprinted polymers. --- Molecular imprinting. --- Imprinting, Molecular --- Imprinting, Polymer --- Polymer imprinting --- polymers --- imprinting --- separation --- sensors --- biomedical materials --- Polymerization --- Polymers